Publications

Highlighted discoveries

Submitted

79. Jaciuch, D., Munns, J., Chawla, S., Davis, S.J. and Juusola, M. (2024) 'Selective human tau protein expression in different clock circuits of the Drosophila brain disrupts different aspects of sleep and circadian rhythms'. doi: https://doi.org/10.1101/2020.12.14.422675

Peer-reviewed original articles accepted, in print or in press

78. Juusola, M., Takalo, J., Kemppainen, J., Razban Haghighi, K., Scales, B., McManus, J., Bridges, A., MaBouDi, H. and Chittka, L. (2024) 'Theory of morphodynamic information processing: linking sensing to behaviour'. Vision Research (in press) https://www.preprints.org/manuscript/202308.1210/v1

77. Bridges, A.D., Royka, A., Wilson, T., Lockwood, C., Richter, J., Juusola, M. and Chittka, L. (2024) 'Bumblebees socially learn behaviours too complex to innovate alone', Nature 627: 572–578. doi: https://doi.org/10.1038/s41586-024-07126-4

76. Kemppainen, J., Mansour, N., Takalo, J. and Juusola, M. (2022) 'High-speed imaging of light-induced photoreceptor microsaccades in compound eyes', Communications Biology 5: 203. doi: https://doi.org/10.1101/2021.07.22.453335

75. Kemppainen, J., Scales, B., Razban Haghighi, K., Takalo, J., Mansour, N., McManus, J., Leko, G., Saari, P., Hurcomb, J., Antohi, A., Suuronen, J-P., Blanchard, F., Hardie, R.C., Song, Z., Hampton, M., Eckermann, M., Westermeier, F., Frohn, J., Hoekstra, H., Lee, C-H., Huttula, M., Mokso, R. and Juusola, M. (2022) 'Binocular Mirror-Symmetric Microsaccadic Sampling Enables Drosophila Hyperacute 3D-Vision', Proc Natl Acad Sci USA, 119: 12, e210971711. doi: https://doi.org/10.1101/2021.05.03.442473

74. Li, X., Abou Tayoun, A., Song, Z., Dau, A., Rien, D., Jaciuch, D., Dongre, S., Blanchard, F., Nikolaev, A., Zheng, L., Bollepalli, M.K., Chu, B., Hardie, R.C., Dolph, P.J. and Juusola, M. (2019) 'Ca2+-activated K+ channels reduce network excitability, improving adaptability and energetics for transmitting and perceiving sensory information', J Neurosci 39: 7132-7154. doi: https://doi.org/10.1523/JNEUROSCI.3213-18.2019

73. Juusola, M., Dau, A., Song, Z., Solanki, N., Rien, D., Jaciuch, D., Dongre, S., Blanchard, F., de Polavieja, G.G., Hardie, R.C. and Takalo, J. (2017) 'Microsaccadic sampling of moving image information provides Drosophila hyperacute vision', eLife 2017;6:e26117. doi: https://doi.org/10.7554/eLife.26117

72. Song, Z., Zhou, Y. and Juusola, M. (2017) 'Modelling elucidates how refractory period can provide profound nonlinear gain control to graded potential neurons', Physiol Rep 5(11): e13306, 1-10. Download publication (PDF, 519KB)

71. Friederich, U., Billings, Hardie, R.C., Juusola, M. and Coca, D. (2016) 'Fly photoreceptors compute phase congruency', PLoS one 11(6): e0157993. Download publication (PDF, 3.2MB)

70. Song, Z., Zhou, Y. and Juusola, M. (2016) 'Random photon absorption model elucidates how early gain control in fly photoreceptors arises from quantal sampling', Front Comput Neurosci 10 (61): 1-13. Download publication (PDF, 2.6MB)

69. Dau, A., Friederich, U., Dongre, S., Li, X., Bollepalli, M.K., Hardie, R.C. and Juusola, M. (2016) 'Evidence for dynamic network regulation of Drosophila photoreceptor function from mutants lacking the neurotransmitter histamine', Front Neural Circuits, 10 (19): 1-22. Download publication (PDF, 4.4MB)

68. Juusola, M., Dau, A., Zheng, L. and Rien, D. (2016) 'Electrophysiological method for recording intracellular voltage responses of Drosophila photoreceptors and interneurons to light stimuli in vivo', J Vis Exp 112: e54142. Jove video. Download publication (PDF, 2.7MB)

67. Randall, A.S., Chu, B., Liu, C.-H., Zhang, Q., Dongre, S., Juusola, M., Wakelam, M., Franze, K. and Hardie, R. C. (2015) 'Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids', J Neurosci 35: 2731-2746. Download publication (PDF, 1.4MB)

66. Song, Z. and Juusola, M. (2014) 'Refractory Sampling Links Efficiency and Costs of Sensory Encoding to Stimulus Statistics', J Neurosci 34: 7216 –7237.

65. Li, M., Liu, F., Juusola, M. and Tang, S. (2014) 'Perceptual color map in macaque visual area V4', J Neurosci 34: 202-217.

64. Heimonen, K., Immonen, E.-V., Frolov, R., Salmela, I., Juusola, M., Vähäsöyrinki, M. and Weckström, M. (2012) 'Signal coding in cockroach photoreceptors is tuned to dim environments', J Neurophysiol 108: 2641-2652. Download publication (PDF, 1MB)

63. Song, Z., Postma, M., Billings, S. A., Coca, D., Hardie, R. C. and Juusola, M. (2012) 'Stochastic, Adaptive Sampling of Information by Microvilli in Fly Photoreceptors', Curr Biol 22: 1371-1380.

62. Wardill, T. J., List, O., Li, X., Dongre, S., McCulloch, M., Ting, C. Y., O’Kane, C. J., Tang, S., Lee, C. H., Hardie, R. C. and Juusola, M. (2012) 'Multiple Spectral Inputs Improve Motion Discrimination in the Drosophila Visual System', Science 336: 925-931.

61. Lipscomb, L., Parkin, C. A., Juusola, M. and Winder, S. J. (2011) 'The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish', PLoS Currents: Muscular Dystrophy, 3: RRN1286. Download publication (PDF, 341KB)

60. Abou Tayoun, A. N., Li, X., Chu, B., Hardie, R. C., Juusola, M. and Dolph, P. J. (2011) 'The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network', J Neurosci 31: 13897-13910.

59. Gonzalez-Bellido, P. T., Wardill, T. J. and Juusola, M. (2011) 'Compound eyes and retinal information processing in miniature dipteran species match their specific ecological demands', Proc Natl Acad Sci USA 108: 4224-4229.

58. Tang, S. and Juusola, M. (2010) 'Intrinsic Activity in the Fly Brain Gates Visual Information during Behavioral Choices', PLoS one 5(12): e14455.

57. Gonzalez-Bellido, P. T., Wardill, T. J., Kostyleva, R., Meinertzhagen, I. A. and Juusola, M. (2009) 'Overexpressing Temperature-Sensitive Dynamin Decelerates Phototransduction and Bundles Microtubules in Drosophila Photoreceptors', J Neurosci 29: 14199-14210. doi: https://doi.org/10.1523/JNEUROSCI.2873-09.2009. Download publication (PDF, 1MB)

56. Nikolaev, A., Zheng, L., Wardill, T. J., O'Cane, C. J., de Polavieja, G. G. and Juusola, M. (2009) 'Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms', PLoS one 4(1): e4306. Download publication (PDF, 846KB)

55. Zheng, L., Nikolaev, A., Wardill, T. J., O'Cane, C. J., de Polavieja, G. G. and Juusola, M. (2009) 'Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics', PLoS one 4(1): e4307.

54. Pantazis, A., Segaran, A., Liu, C.-H., Nikolaev, A., Rister, J., Thum, A., Roeder, T., Semenov, E., Juusola, M., Hardie, R. C. (2008) 'Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse', J Neurosci 28: 7250-7259. Download publication (PDF, 2.6MB)

53. Faivre, O. C. and Juusola, M. (2008) 'Visual coding in locust photoreceptors', PLoS one 3(5): e2173.

52. McQuibban, G. A., Lee, J. R., Zheng, L., Juusola, M. and Freeman, M. (2006) 'Rhomboid-7 regulates mitochondrial dynamics and contributes to Drosophila lifespan and neuronal function', Curr Biol 16: 982-989. Download publication (PDF, 577KB)

51. Zheng, L., de Polavieja, G. G., Wolfram, W., Asyali, M. H., Hardie, R. C. and Juusola, M. (2006) 'Feedback network controls photoreceptor output at the layer of first visual synapses in Drosophila', J Gen Physiol 127: 495-510.

50. Vähäsöyrinki, M., Niven, J. E., Hardie, R. C., Weckström, M. and Juusola, M. (2006) 'Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels', J Neurosci 26: 2652–2660. Download publication (PDF, 810KB)

49. de Polavieja, G. G., Harsch, A., Kleppe, I., Robinson, H. P. C. and Juusola, M. (2005) 'Stimulus history reliably shapes action potential waveforms of cortical neurons', J Neurosci 25: 5657-5665.

48. Asyali, M. H. and Juusola, M. (2005) 'Use of Meixner functions in estimation of Volterra kernels of nonlinear systems with delay', IEEE Trans Biomed Eng 52: 229-237. Download publication (PDF, 364KB)

47. Wolfram, W. and Juusola, M. (2004) 'The impact of rearing conditions and short-term light exposure on signalling performance in Drosophila photoreceptors', J Neurophysiol 92: 1918-1927. Download publication (PDF, 310KB)

46. Niven, J. E., Vähäsöyrinki, M., Juusola, M. and French, A. S. (2004) 'Interaction between light induced currents, voltage-gated currents and input statistics in Drosophila photoreceptors', J Neurophysiol 91: 2696-2706. Download publication (PDF, 524KB)

45. Juusola, M., Niven, J. E. and French, A. S. (2003) 'Shaker K+ channels contribute an early nonlinear amplification to the light response in Drosophila photoreceptors', J Neurophysiol 90: 2014-2021. Download publication (PDF, 360KB)

44. Juusola, M. and de Polavieja, G. G. (2003) 'The rate of information transfer of naturalistic stimulation by graded potentials', J Gen Physiol 122: 191-206.

43. Niven, J. E., Vähäsöyrinki, M. and Juusola, M. (2003) 'Shaker K+ channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors', Proc R Soc Lond B 270: 58-61. Download publication (PDF, 102KB)

42. Niven, J. E., Vähäsöyrinki, M., Kauranen, M., Hardie, R. C., Juusola, M*. and Weckström, M. (2003) 'The contribution of Shaker K+ channels to the information capacity in Drosophila photoreceptors', Nature 421: 630-634. (* the corresponding author)

41. Hardie, R. C., Martin, F., Cochrane, G. R., Juusola, M., Georgiev, P. and Raghu, P. (2002) 'Molecular Basis of amplification in Drosophila phototransduction: roles for G protein, phosphlipase C and diacylglycerol kinase', Neuron 36: 689-701. Download publication (PDF, 480KB)

40. Hardie, R. C., Raghu, P., Moore, S., Juusola, M., Baines, R. and Sweeney, S. (2001) 'Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors', Neuron 30: 149-159. Download publication (PDF, 322KB)

39. Juusola, M. and Hardie, R. C. (2001) 'Light-adaptation in Drosophila photoreceptors: II Rising temperature increases the bandwidth of reliable signalling', J Gen Physiol 117: 27-42. Download publication (PDF, 343KB)

38. Juusola, M. and Hardie, R. C. (2001) 'Light-adaptation in Drosophila photoreceptors: I Response dynamics and signaling efficiency at 25oC', J Gen Physiol 117: 3-25.

37. Marmarelis, V. Z., Juusola, M. and French, A. S. (1999) 'Principal dynamic mode analysis of nonlinear transduction in a spider mechanoreceptor', Ann Biomed Eng 27: 391-402. Download publication (PDF, 263KB)

36. Juusola, M. and French, A. S. (1998) 'The adaptation properties of two types of sensory neurons in a spider mechanoreceptor organ', J Neurophysiol 80: 2781-2784. Download publication (PDF, 85KB)

35. Korenberg, M. J., Juusola, M. and French, A. S. (1998) 'Two methods for calculating the responses of photoreceptors to moving objects', Ann Biomed Eng 26: 308-314. Download publication (PDF, 96KB)

34. Juusola, M. and French, A. S. (1997) 'Efficiency of sensory information coding by mechanoreceptor neurons', Neuron 18: 959-968.

33. Juusola, M., Seyfarth, E. A. and French, A. S. (1997) 'Rapid coating of class-capillary microelectrodes for single-electrode voltage-clamp', J Neurosci Meth 71: 199-204. Download publication (PDF, 350KB)

32. Juusola, M. and French, A. S. (1997) 'Visual acuity for moving objects in first and second order neurons of the fly compund eye', J Neurophysiol 77: 1487-1495.

31. Juusola, M., Weckström, M., Uusitalo, R. O., Korenberg, M. and French, A. S. (1995) 'Nonlinear models of the first synapse in the light-adapted fly retina', J Neurophysiol 74: 2538-2547.

30. Juusola, M. and French, A. S. (1995) 'Transduction and adaptation in spider split sense organ mechanoreceptors', J Neurophysiol 74: 2513-2523. Download publication (PDF, 2.4MB)

29. Juusola, M. and French, A. S. (1995) 'Recording from cuticular mechanoreceptors during mechanical stimulation', Pflüger Arch 431: 125-128. Download publication (PDF, 478KB)

28. Uusitalo, R. O., Juusola, M., Kouvalainen, E. and Weckström, M. (1995) 'Tonic transmitter release in a graded potential synapse', J Neurophysiol 74: 470-473. Download publication (PDF, 982KB)

27. Uusitalo, R. O., Juusola, M. and Weckström, M. (1995) 'Graded and spiking responses in identified first order visual interneurons of the fly compound eye', J Neurophysiol 72: 1782-1792. Download publication (PDF, 2.5MB)

26. Weckström, M., Juusola, M., Uusitalo, R. O. and French, A. S. (1995) 'Fast-acting compressive and facilatory nonlinearities in light-adapted fly photoreceptors', Ann Biomed Eng 23: 70-77. Download publication (PDF, 707KB)

25. Juusola, M., Uusitalo, R. and Weckström, M. (1995) 'Transfer of graded potentials at the photoreceptor-interneuron synapse', J Gen Physiol 105: 117-148.

24. Juusola, M., Seyfarth, E. A. and French, A. S. (1994) 'The sodium-dependent receptor current in a new mechanoreceptor preparation', J Neurophysiol 72: 3026-3028. Download publication (PDF, 647KB)

23. Kouvalainen, E., Weckström, M. and Juusola, M. (1994) 'Determination of signal-to-noise ratio and linearity in light-adapted blowfly photoreceptors', Vis Neurosci 95: 1221-1225. Download publication (PDF, 438KB)

22. Juusola, M., Kouvalainen, E., Järvilehto, M. and Weckström, M. (1994) 'Contrast gain, signal-to-noise ratio and linearity in light-adapted blowfly photoreceptors', J Gen Physiol 104: 593-621.

21. Juusola, M. (1994) 'Measuring complex admittance and receptor current by single electrode voltage-clamp', J Neurosci Meth 53: 1-6. Download publication (PDF, 538KB)

20. French, A. S., Korenberg, M., Järvilehto, M., Kouvalainen, E., Juusola, M. and Weckström, M. (1993) 'The dynamic nonlinear behavior of fly photoreceptors evoked by a wide range of light intensities', Biophys J 65: 832-839. Download publication (PDF, 772KB)

19. Juusola, M. and Weckström, M. (1993) 'Band-pass filtering by voltage-dependent membrane in an insect photoreceptor', J Neurosci Lett 154: 84-88. Download publication (PDF, 397KB)

18. Juusola, M. (1993) 'Linear and non-linear contrast coding in light adapted blowfly photoreceptors', J Comp Physiol A 172: 511-521.

17. Weckström, M., Juusola, M. and Laughlin, S. (1992) 'Presynaptic enhancement of signal transients in photoreceptor terminals in the compound eye', Proc R Soc B Lond 250: 83-89. Download publication (PDF, 1.1MB)

16. Weckström, M., Kouvalainen, E. and Juusola, M. (1992) 'Measurement of cell impedance in frequency domain using discontinuous current clamp and white noise modulated current injection', Pflüger Arch 421: 469-472. Download publication (PDF, 383KB)

Peer-reviewed review articles

15. Song, Z., Zhou, Y., Feng, J. and Juusola, M. (2021) 'Multiscale 'whole-cell' models to study neural information processing – new insights from fly photoreceptor studies', J Neurosci Meth 357: 109156. View publication

14. Juusola, M. and Song, Z. (2017) 'How a Fly Photoreceptor Samples Light Information in time', J Physiol Lond 595: 5427-5437. Download publication (PDF, 1.4MB)

13. Song, Z. and Juusola, M. (2017) 'A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range', J Physiol Lond 595: 5439-5456. Download publication (PDF, 1.8MB)

12. Hardie, R. C. and Juusola, M. (2015) 'Phototransduction in Drosophila', Curr Opin Neurobiol 34: 37-45. Download publication (PDF, 1.6MB)

11. Juusola, M., Robinson, H. P. C. and de Polavieja, G. G. (2007) 'Coding with spike shapes and graded potentials in cortical networks', BioEssays 29: 178-187. Download publication (PDF, 449KB)

10. Juusola, M., French, A. S., Uusitalo, R. O. and Weckström, M. (1996) 'Information processing by graded potential transmission through tonically active synapses', Trends Neurosci 19: 292-297. Download publication (PDF, 641KB)

Book chapters and peer-reviewed conference proceedings

9. Juusola, M., Song, Z. and Hardie, R. C. (2015) 'Phototransduction biophysics', Encyclopedia of Computational Neuroscience, Springer-Verlag, pp 2359-2376.

Download publication (PDF, 824KB)

8. Friederich, U., Billings, S. A., Juusola, M. and Coca, D. (2012) 'Reverse Engineering Gain Adaptation in Sensory Systems', Acta Press, Proceedings of the 9th IASTED International Conference on Biomedical Engineering. doi: http://dx.doi.org/10.2316/P.2012.764-125

7. Song, Z., Billings, S., Coca, D., Postma, M., Hardie, R. C. and Juusola, M. (2009) 'Biophysical Modeling of a Drosophila Photoreceptor', Lect Notes Comp Sci (ICONIP 2009, Part I) 5863: 57–71.

6. Friederich, U., Coca, D., Billings, S. and Juusola, M. (2009) 'Data Modelling for Analysis of Adaptive Changes in Fly Photoreceptors', Lect Notes Comp Sci (ICONIP 2009, Part I) 5863: 34–48.

5. de Polavieja, G. G., Harsch, A., Robinson, H. P. C. and Juusola, M. (2005) 'Slow conductances encode stimulus history into spike shapes', Lect Notes Comp Sci 3561: 150-155.

4. Weckström, M., Juusola, M. and Uusitalo, R. O. (2000) 'Synaptic signal transfer in the graded potential synapse', In Neuroscience Finland 1999. Invited lectures and abstracts of short communications. (ed. Weckström, M.). Acta Universitatis Ouluensis Medica. pp. 25-29.

3. Juusola, M. and French, A. S. (1998) 'Signal encoding in spider slit-sense organ mechanoreceptor neurons', In From structure to information in sensory systems (eds. Teddei-Ferretti C. & Musio C). pp. 254-265. World Scientific, Singapore, New Jersey, London, Hong Kong. 30.

2. Juusola, M., Uusitalo, R. O. and Weckström, M. (1998) 'Optimizing the flow of information by early visual processing', In From structure to information in sensory systems (eds. Teddei-Ferretti C. & Musio C). pp. 412-430. World Scientific, Singapore, New Jersey, London, Hong Kong. 29.

Books

1. Juusola, M. (1993) 'Contrast coding in dipteran photoreceptors, the role of phototransduction and the cell membrane', Acta Univ Oulu 142 pp. ISBN 951-42-3629-7; ISSN 0355-3221.